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Use of Mini-fluid Challenge for Fluid Responsiveness Prediction During One-lung Ventilation

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02858115
Enrollment
50
Registered
2016-08-08
Start date
2014-01-31
Completion date
2016-08-31
Last updated
2016-08-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Circulatory Failure During One-lung Ventilation Surgery

Brief summary

During thoracic surgery, an excessive use of fluid results in pulmonary complications. Dynamic fluid responsiveness predictors are not easily usable during one lung ventilation. The investigators hypothesized that the assessment by transesophageal echocardiography (TEE) of subaortic velocity time index (VTI) variation after 100 ml of crystalloid would predict fluid responsiveness in patients receiving one-lung ventilation. This retrospective, observational, single center study was from January 2014 to December 2015. The investigators included 105 patients requiring one lung ventilation lung resection. The investigators analysed 39 patients presenting an acute circulatory failure. 100 ml of crystalloid was infused over 1-min. After an echocardiographic assessment at 1-min, remaining 400 ml were administered over 14-min Fluid responsiveness was defined as an increase in the VTI above 15% after infusion of 500 ml of crystalloid.

Interventions

OTHERFluid challenge

100 ml of crystalloid was infused over 1-min

OTHERTrans-oesophageal echography

an echocardiographic assessment at 1-min,

Sponsors

Assistance Publique Hopitaux De Marseille
Lead SponsorOTHER

Study design

Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Lung resection * Acute circulatory failure * One-lung ventilation

Exclusion criteria

* Sinusal rhythm

Design outcomes

Primary

MeasureTime frameDescription
Fluid responsivenessone dayincrease of cardiac output of more than 15%
Velocity time indexone day: Echographic assesment of cardiac output

Secondary

MeasureTime frameDescription
Pulsed pressure variationone daydynamic indice of fluid responsiveness

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026