Depression
Conditions
Keywords
rhythm, depression, antidepressant treatment
Brief summary
The study aims to characterize the rhythmic parameters of unipolar depressed patients that are associated with the response to antidepressants after 6 weeks of treatment.
Detailed description
Patients are included at the time of their hospitalization in the psychiatry unit. They perform rhythmic parameters recording within 48hours after the initiation of the antidepressant treatment. An evaluation of the evaluation of the severity of depression symptoms is performed at 2, 4 and 6 weeks after the initiation of the antidepressant treatment. A correlation analysis will be performed with rhythmic parameters and the response to the antidepressant treatment.
Interventions
OTHERrhythmic parameter recording
the following rhythmic parameters are recording during 48 hours: temperature, heart rate and actimetry
BEHAVIORALpsychiatric assessment
different psychometric scales are filled in: Montgomery and Asberg depression rating scale (MADRS), Quick inventory depression scale (QIDS-C16) and Beck depression inventory (BDI)
Sponsors
Centre Hospitalier Universitaire Dijon
University Hospital, Strasbourg, France
Centre Hospitalier Universitaire de Besancon
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* current unipolar major depressive disorder according to the Diagnostic ans Statistics Manual (DSM)V * MADRS score \> 25
Exclusion criteria
* other psychiatric disorder * current treatment with thymoregulating agent * clozapine treatment * heart disease that could alter heart rate characteristics * disease associated with fever * shift work within 3 months before inclusion * transmeridian travel in the preceding month * guardianship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| significant difference of temperature amplitude between responder and non-responder | 6 weeks | the response to the antidepressant treatment is determined by the variation of the MADRS score between pretreatment and 6 weeks of treatment. the complete response is obtained when the MADRS score has at least a 50% decrease after 6 weeks. |
| significant difference of activity duration between responder and non-responder | 6 weeks | — |
| significant difference of RR interval of the heart rate between responder and non-responder | 6 weeks | — |
Countries
France
Contacts
Primary Contactjulie monnin, PhD
Backup ContactSophie Depierre
Outcome results
None listed