Choroid
Conditions
Keywords
Energy drink, Choroid
Brief summary
The choroid is a richly vascularized conjunctive tissue, providing the nutritive elements to the pigmentary epithelium and the photoreceptors of the retina. It drains 80% of the eye's blood. The choroidal thickness fluctuates according to the state of fullness of its constitutive vessels. The choroid and the neuroretina (separate by the pigmentary epithelium) are intimately linked and are subject to modifications during the ingestion of caffeine and taurine combined. Several authors have shown a significant decrease of the choroidal thickness lasting at least 4 hours after the ingestion of a small coffee. This decrease may be caused by caffeine's vasoconstrictor effect. Taurine is the most abundant amino acid in the retina. Recent studies have shown the importance of this amino acid in the physiology of both, retinal pigmentary epithelium and retinal ganglion cells. RedBull® is an energizing drink, where one single 25 cl can contains 80 mg of caffeine (the equivalent of a coffee mug) and 1 g of taurine. This pilot trial aims to study the variations of the choroidal thickness and to describe possible modifications within the pigmentary epithelium, due to the ingestion of caffeine and taurine. The results of this study will act as a reference for an ulterior trial aiming specific choroidal pathologies of young patients, such as the central serous chorioretinitis.
Interventions
DIETARY_SUPPLEMENTRedBull® energy drink
Subjects consume 25 mL of RedBull® energy drink
Sponsors
Fondation Ophtalmologique Adolphe de Rothschild
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Ages 18-45 years old * subject under no medical treatment who can alter choroidal depth (sildenafil, diuretics, steroids, etc) * Non smoker * subject who has not ingested any caffeine within the 12 hours prior to the trial's inclusion * subject well informed of the trial and having signed consent
Exclusion criteria
* subject with retinal and/or choroidal abnormalities * Diabetic subject * Hypermetropia \> +3 diopters and myopia \< -3 diopters * History of intra-ocular surgery or laser * subject with a history of retinal pathologies * Subject not affiliated to French social security * Subject under juridical protection * Pregnant woman
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intra-patient variation of the choroidal thickness | up to 4 hours | Measure of choroidal thickness by Optical Coherence Tomography (OCT), 5 minutes before ingesting 25cl RedBull® then 5 minutes, 30 minutes, 1 hour, 2 hours and 4 hours after ingestion of RedBull®. |
Countries
France
Outcome results
None listed