Ovarian Function Insufficiency
Conditions
Brief summary
Ovarian cryopreservation is one of the available option for preserving fertility prior to potentially sterilizing treatments. In the absence of other techniques such as in vitro folliculogenesis or injection of isolated ovarian follicles, this tissue can only be re-used by autograft. In France, the first live birth after orthotopic ovarian transplantation, was obtained by Roux et al. in 2009. This clinical trial aims to build a cohort of patients likely to use their ovarian tissue cryopreserved by autograft.
Detailed description
Ovarian cryopreservation is one of the available option for preserving fertility prior to potentially sterilizing treatments. In the absence of other techniques such as in vitro folliculogenesis or injection of isolated ovarian follicles, this tissue can only be re-used by autograft. In France, the first live birth after orthotopic ovarian transplantation, was obtained by Roux et al. in 2009. This clinical trial aims to build a cohort of patients likely to use their ovarian tissue cryopreserved by autograft. This cohort will be used to: * Follow up of patients with their cryopreserved ovarian tissue; * Evaluate requests for ovarian tissue grafting ; * Propose a search of residual disease in case of neoplastic disease risk (if possible); * Allowing patients to benefit from an ovarian tissue autograft; * Assess the effectiveness of autograft technique after the restoration of ovarian function.
Interventions
None listed
Sponsors
CHU de Reims
University Hospital, Marseille
University Hospital, Lille
Central Hospital, Nancy, France
University Hospital, Grenoble
CMCO SIHCUS, Schiltingheim
University Hospital, Bordeaux
Nantes University Hospital
University Hospital, Limoges
Centre Hospitalier Universitaire de Besancon
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
FEMALE
Age
11 Years to 43 Years
Healthy volunteers
No
Inclusion criteria
* Patients who have cryopreserved their ovarian tissue; * Patients with premature ovarian insufficiency; * Patients older than 11 years (bone age) for induction of puberty; * Patients aged from 18 to 43 years for the restoration of ovarian function; * No objection from the patient * Patients who have already received ovarian tissue autograft.
Exclusion criteria
* Patients aged under 11 years (bone age); * Patients older than 43 years; * Patients refusing to be included; * Patients (adults) under guardianship, curators and safeguard justice
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of patient who are candidate to ovarian tissue autograft | 5 years |
Countries
France
Contacts
Primary ContactChlotilde AMIOT, MD, PhD
Outcome results
None listed