Preterm Birth
Conditions
Brief summary
The American Academy of Pediatrics has recommended that growth in size (weight, length, and head circumference) and in body composition (fat and lean mass) in preterm infants should adhere as close as possible to the growth and body composition of a healthy infant in utero at the same gestational age. However, there are no body composition reference curves available at this time for the preterm infant population. The purpose of this study is to collect cross-sectional body composition data using air displacement plethysmography (PEA POD Infant Body Composition System, Life Measurement, Inc) on approximately 240 preterm infants within 3 days of birth, for the purpose of generating means, standard deviations, and percentile values for total body fat mass, total fat free mass, and percent body fat for infants born at 30-36 weeks gestation. Relatively healthy infants without evidence of growth retardation will be selected for form the reference sample. The goal is to generate a set of common reference curves to be used in clinical centers against which to compare body composition status for individual infants.
Interventions
OTHERBody Composition
No intervention. This is an observational, normative study of body composition variation in preterm infants
Sponsors
Santa Clara Valley Medical Center
Baystate Medical Center
University of Minnesota
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
24 Hours to 72 Hours
Healthy volunteers
Yes
Inclusion criteria
* Appropriate for gestational age (AGA), singleton, 30+0 and 36+6 weeks gestational age
Exclusion criteria
* Congenital defects that affect growth * Inability to tolerate room air for 5 minutes without desaturation or bradycardia * \<1 kg birth weight * Parents did not provide consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fat mass | Within 72 hours of birth | Total body fat mass measured by air displacement plethysmography, in kg |
| Fat-free mass | Within 72 hours of birth | Total body fat-free mass measured by air displacement plethysmography, in kg |
| Percent body fat | Within 72 hours of birth | Percent body fat measured by air displacement plethysmography, in % |
Outcome results
None listed