Hemophagocytic Lymphohistiocytosis (HLH), Hemophagocytic Syndromes, Macrophage Activation Syndrome (MAS)
Conditions
Keywords
Ferritin, Hemophagocytic lymphohistiocytosis (HLH), Critically ill patients, intensive care unit (ICU), Outcome, Diagnosis
Brief summary
Retrospective analysis of ferritin, outcome and HLH-criteria in critically ill patients.
Detailed description
The study is a retrospective register study of critically ill patients from Charité - Universitätsmedizin Berlin during 2000 and 2016 that had at least one measurement of plasma ferritin. Outcome, underlying diagnoses and HLH-2004 criteria (Henter JI et al. 2007) will be analyzed and the HScore of these patients will be calculated (Fardet L et al. 2014). All recorded data of the specific admission term in ICU will be used for the analysis. No follow-up of the patients after discharge will be performed in this study. The study does not involve any randomization or any drug testing. Update 2019: We expanded our database for the years until 2018 and also for the surgical and medical ICUs of the Charité - Universitätsmedizin Berlin (from 256 to 2623 patients). Update 2022: A systematic literature search will be performed to find suitable validation cohorts for multicenter validation of optimized HLH diagnostic criteria, which are calculated based on our data (new secondary endpoint).
Interventions
None listed
Sponsors
Gunnar Lachmann
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* male and female patients * at least one measurement of plasma ferritin
Exclusion criteria
-age below 18 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality | Participants will be followed up for the duration of hospital stay, an expected average of two months | A retrospective analysis of patients with available charts to determine the outcome whether patients survived the ICU or died. |
| Probability of having undiagnosed Hemophagocytic lymphohistiocytosis (HLH) | The participants will be followed up for the duration of hospital stay, an expected average of two months | Retrospective analysis of available charts, underlying diagnoses, findings and blood values: HLH-2004 criteria (Henter JI et al. 2007) and HScore (Fardet L et al. 2014) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Diagnoses | Participants will be followed up for the duration of hospital stay, an expected average of two months | Retrospective analysis of available charts and underlying diagnoses |
| Intensive care unit stay | Participants will be followed up for the duration of intensive care unit stay, an expected average of one week | Retrospective analysis of available charts and duration of ICU stay |
| Improving HLH diagnostic criteria including multicenter validation | Participants will be followed up for the duration of intensive care unit stay, an expected average of one week | Sensitivity and specificity of HLH diagnostic criteria should be improved by calculating different cutoffs of HLH-2004 criteria. Combinations with highest sensitivity and specificity will be validated in published cohorts of HLH testing for sensitivity and specificity. |
Outcome results
None listed