Cardiovascular Disease, Childhood Obesity, Endothelial Dysfunction, Hypertension
Conditions
Keywords
arterial stiffness, retinal vessels, physical activity, children
Brief summary
The project is designed as a large scale, cross-sectional study. The aim of the study is to investigate the association of micro- and macrovascular function with physical fitness and body composition in primary school children.
Detailed description
The investigators will examine whether physical fitness, body composition and blood pressure differently affect large and small arteries in young children. Furthermore, the investigators will examine whether pulmonary dysfunction is associated with vascular disorders and if subcutaneous advanced glycation endproducts (AGE's) mediate some of the vascular alterations observed.
Interventions
BEHAVIORALPhysical Activity, 20-meter shuttle run
cross-sectional physical activity assessment and medical screeening
Sponsors
University of Basel
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
6 Years to 8 Years
Healthy volunteers
Yes
Inclusion criteria
* primary school children aged 6-8 years who can participate in physical education lessons with written consent from their parents.
Exclusion criteria
* children with a medical certificate that prohibits physical exercise with no consent from their parents.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Association of arterial stiffness (pulse wave velocity) with physical fitness in primary school children | Through study completion, an average of 1 year. | Oscillometric calculation of central pulse wave velocity. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association of arteriolar-to-venular diameter ratio (AVR) with physical fitness in primary school children | Through study completion, an average of 1 year. | Retinal vessel diameters by use of Static Retinal Vessel Analyzer (SVA-T). |
| Association of subcutaneous advanced glycation endproducts (AGEs) with body composition, blood pressure and physical fitness | Through study completion, an average of one year. | Non-invasive, subcutaneous measurement of AGEs (skin autofluorescence). |
| Association of lung function (FEV1/VC) with body composition, blood pressure and physical fitness | Through study completion, an average of one year. | Handheld spirometer (EasyOne Diagnostic) to measure vital capacity (VC), peak expiratory flow (PEF), forced expiratory volume (FEV1) and the ratio of FEV1/VC. |
Countries
Switzerland
Outcome results
None listed