Hypocalcemia
Conditions
Brief summary
150 patients divided into two groups.The experimental group was submitted at the assay of iPTH six hours after surgery whilst the control group was submitted to a daily assay of serum calcium and phosphorus.
Detailed description
Purpose: The aim of this randomized controlled trial was to validate the results of a previous prospective cohort study conducted in the same surgical unit regarding the use of concomitant intact parathyroid hormone (iPTH) and serum calcium measurement in predicting hypocalcemia after total thyroidectomy. Methods: From January 2014 to January 2015, 150 patients underwent total thyroidectomy in our department and were divided into two groups. The experimental group was submitted at the assay of iPTH six hours after surgery whilst the control group was submitted to a daily assay of serum calcium and phosphorus. Sensitivity and specificity of different serum measurements have been calculated using the Receiver-operator characteristics (ROC) curve.
Interventions
OTHERiPTH
iPTH assay six hours after surgery
OTHERno dosage of iPTH
Ca and P on postoperative day 1 and 2
Sponsors
University of Cagliari
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Be submitted to total thyroidectomy during the study period * Have signed the informed consent
Exclusion criteria
* Lack of inclusion criteria * Lobectomy with isthmusectomy or partial or subtotal thyroidectomy * Completion thyroidectomy * Concomitant hyperparathyroidism was present * Concomitant treatment with oral calcium and/or vitamin D prior to surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sensibility and specificity of iPTH and serum calcium measurement | 1 month | Sensitivity and specificity of serum measurement using the Receiver-operator characteristics (ROC) curve |
Outcome results
None listed