Schizophrenia
Conditions
Keywords
Emotion, motivation, cognition, schizophrenia
Brief summary
Anhedonia and avolition reflect emotional and motivational disorders, respectively. However, if these disorders play a major role in the symptomatology of schizophrenia, their mechanisms remain poorly understood, and existing treatments are inefficient on these symptoms. The literature suggests that the impairment does not concern emotion or motivation per se, but rather their influence on cognition. This project aims at using recent advances in the fundamental domain to better understand the cognitive and neuronal mechanisms of the patients' alterations, and especially how emotion and motivation influence cognition in schizophrenia.
Interventions
OTHERElectroencephalogram
electrophysiological measurements (evoked potentials) based on neural activity when visualizing stimuli
BEHAVIORALCognitive tasks
\- clinical scales and subjective assessments of emotional and motivational stimuli
BEHAVIORALsubjective evaluation scales
\- clinical scales and subjective assessments of emotional and motivational stimuli
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
University Hospital, Strasbourg, France
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* diagnostic and Statistical Manual of Mental Disorders criteria for schizophrenia
Exclusion criteria
* addiction problem * invalidating visual sensory problems * neurological history * for the healthy volunteers: psychiatric history
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in the amplitude of the CNV (Contingent Negative Variation) as a function of the primer displayed on the screen | During EEG sessions, at experimental session 1 (Day 0) and experimental session 2 (up to Day 120) | Before each cognitive trial a primer will be displayed, which will be either neutral or convey emotion or motivation. The investigators will check whether this primer affects the subjects preparation by measuring the CNV, which is an evoked potential recorded with electroencephalography, and indexing preparatory effort. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in the amplitude of the LPP (Late Positive Potential) as a function of the primer displayed on the screen | During EEG sessions, at experimental session 1 (Day 0) and experimental session 2 (up to Day 120) | The investigators will check whether primers affect the subjects attention by measuring the LPP, which is an evoked potential recorded with electroencephalography, and indexing sustained attention. |
Countries
France
Outcome results
None listed