Urinary Markers of Detrusor Overactivity in Spina Bifida Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02852317

Acronym

BUHD-SPINA

Enrollment

134

Registered

2016-08-02

Start date

2015-03-16

Completion date

2017-07-17

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis, Overactive Bladder, Spina Bifida, Spinal Cord Injury

Brief summary

The purpose of this study is to assess diagnostic performance of urinary markers of detrusor overactivity (Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), adenosine triphosphate (ATP), Prostaglandine E2) in detected high pressure bladder un spina bifida patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Study arm: * Spina bifida patient * Seen consecutively in outpatient clinics * Age \> 18 years-old Control arm: * Patients with multiple sclerosis or spinal cord injury or overactive bladder * Seen consecutively in urodynamics * with lower urinary tract symptoms * Age \> 18 years-old

Exclusion criteria

* Positive urine culture * History of urologic neoplasms * History of interstitial cystitis

Design outcomes

Primary

Measure	Time frame
Accuracy of urinary markers will be evaluated by area under the curve (AUC)	through study completion, an average of 1 year

Countries

France

Outcome results