Gastric Cancer, HER-2
Conditions
Keywords
gastric cancer, Her2/neu, dual paraffin blocks, trastuzumab
Brief summary
One paraffin block is routinely used for Human Epidermal Growth Factor Receptor 2 (Her2/neu) immunohistochemistry (IHC) assessment. Here, investigators investigated if picking two or multiple paraffin blocks for Her2/neu evaluation is an economical, efficient and practical method, which may reduce false-negativity of Her2/neu IHC assessment due to intratumoral heterogeneity.
Interventions
OTHERDual or Multiple Paraffin Blocks
Assessing Her2/Neu Expression in Gastric Cancer With Dual or Multiple Tumor Tissue Paraffin Blocks
OTHEROne Paraffin Blocks
Assessing Her2/Neu Expression in Gastric Cancer With One Tumor Tissue Paraffin Blocks
Sponsors
Shanghai Zhongshan Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Age between 18 to 80; Received curative surgery with primary gastric adenocarcinoma; Did not receive any preoperative treatment.
Exclusion criteria
None.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The positive rate of cohort using dual or multiple tumor tissue paraffin blocks | 24 months |
Countries
China
Contacts
Primary ContactYingyong Hou, M.D. & Ph.D.
Outcome results
None listed