Cardiomyopathy
Conditions
Brief summary
The aim of this project is to identify common genetic polymorphisms associated with the occurrence of rhythmic events in patients with severe cardiomyopathy.
Interventions
GENETICIdentification of genetic polymorphisms
Sponsors
Nantes University Hospital
Study design
Observational model
OTHER
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients implanted for primary prevention, an implantable cardioverter defibrillator (ICD) single or double room, for severe cardiomyopathy (EF \<35%) * Patients with ischemic cardiomyopathy or idiopathic dilated cardiomyopathy.- Appropriate treatment group: patients who had a rhythmic event (before or after inclusion) appropriately treated either by administering an electric shock or by antiarrhythmic stimulation * Group no event patients who have never received treatment or electrical antiarrhythmic stimulation and with a minimum follow-up of three years before inclusion and did not receive proper treatment during the follow up period of the study
Exclusion criteria
* Patients implanted with an ICD for primary prevention in the context of a family hereditary disease (long QT syndrome, Brugada syndrome, hypertrophic cardiomyopathy, ventricular tachycardia catecholergic right ventricular dysplasia ...). * Patients with left ventricular function greater than 35%. * Patients implanted with a defibrillator function resynchronization. * Patients minors, adults under guardianship and protected persons are eligible under this project.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of polymorphisms pre-selected candidates (or by direct sequencing by High Resolution Melting). | 4 years |
| Identification of polymorphisms frequent (> 5% in the general population) by association study ( Genome Wide Association Study '(GWAS)) using genotyping technology broadband Axiom (Affymetrix). | 4 years |
Countries
France
Outcome results
None listed