One-Lung Ventilation, Postoperative Respiratory Complications, Driving Pressure
Conditions
Brief summary
This study aims to prove that driving pressure limited ventilation is superior in preventing postoperative pulmonary complications to existing protective ventilation.
Interventions
Positive end expiratory pressure is adjusted to minimize driving pressure, plateau pressure minus end expiratory pressure from 2 to 10 cmH2O during one-lung ventilation
Sponsors
Samsung Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults greater than or equal to 19 years * Patient who undergoes one-lung ventilation for thoracic surgery
Exclusion criteria
* The American Society of Anesthesiologists (ASA) Physical Status classification greater than or equal to 4 * Patient who is contraindicated with application of positive end expiratory pressure * Patient who rejects being enrolled in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of postoperative pulmonary complications | within the first 3 days after surgery | Patient is regarded to have postoperative pulmonary complication when 4 or more positive variables exists according to Melbourne Group Scale. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Partial pressure of oxygen in arterial blood | during surgery | — |
| The ratio of partial pressure arterial oxygen and fraction of inspired oxygen | on the first postoperative day | The ratio will be obtained from the first arterial blood gas analysis on the first postoperative day. |
Countries
South Korea
Outcome results
None listed