Reperfusion Injury
Conditions
Keywords
Postoperative pulmonary complications, Transcutaneous electric acupoint stimulation, pulmonary protection
Brief summary
TEAS might protect against postoperative pulmonary such as ischemia-reperfusion injury (IRI) and atelectasis. We tested the hypothesis that transcutaneous electrical acupoint stimulation protects against postoperative pulmonary complications in patients who are receiving mechanical ventilation during general anesthesia for gynecologic laparoscopic surgery.
Detailed description
Participants: 100 patients who underwent elective gynecologic laparoscopic surgery Methods: We recruited 100 patients who are planned for gynecologic laparoscopic surgery. Patients were enrolled from March 1, 2015. We randomly allocated patients into two groups: controlled group ( patients treated without transcutaneous electrical acupoint stimulation) and TEAS group (patients treated with TEAS on Feishu, Hegu, Chize half an hour before the surgery). Blood pH, Pco2, Po2 and oxygen saturation were measured by an automatic blood gas analyzer immediately after obtaining the samples from the aorta. Sample all the patients blood before and after the surgery. And then measure the level of TNF-α, IL-1β, and IL-6.
Interventions
DEVICEelectroacupuncture
Transcutaneous Electric Acupoint Stimulation which is a device of electroacupuncture was used on patients in TEAS group with the stimulator parameters set as 2/100Hz, 2V, 30min.
Sponsors
Shengjing Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Aged from 65 to 75 * The American Society of anesthesiologists (American Society of Anesthesiology, ASA) class Ⅱ \ III * scheduled for gynecologic laparoscopic surgery under general anesthesia
Exclusion criteria
* pre-existing lung or caridac disease * impaired kidney or liver function * history of bronchial asthma or chronic obstructive pulmonary disease * history of smoking * respiratory infection in the previous 2 weeks * preoperative use of bronchodilator, or a steroid
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the change of blood PO2 in mmHg | intraoperative |
| the change of blood SPO2 in percentage | intraoperative |
| the change of blood pH | intraoperative |
| the change of blood PCO2 in mmHg | intraoperative |
| the change of hemodynamic parameter MAP in mmHg | intraoperative |
| the change of hemodynamic parameters HR in beat per minutes | intraoperative |
Secondary
| Measure | Time frame |
|---|---|
| post-operative pulmonary complications | in the first 5 days after surgery |
| the change of plasma concentration of IL-1β | intraoperative |
| the change of Plasma concentration of TNF-α in pg/mL | intraoperative |
Countries
China
Outcome results
None listed