Physiological Stress, Cognition - Other
Conditions
Brief summary
This research intervention aims to examine the effects of a fermented dairy beverage on changes in behavioral and biological measures of cognition and stress among adults.
Detailed description
Evidence-based dietary strategies provide behavioral means benefiting physical and cognitive function. Pertinent to the proposed work, dietary intake has been recently shown to have the potential to directly influence the gut microbiota composition as well as brain function. Specifically, the consumption of probiotics or foods containing healthful microbial cultures (e.g., fermented milk, yogurts, etc.) are increasingly being recognized as modulators of metabolism, cognition, and stress. These foods are readily available in the marketplace, however, their implications for physical and cognitive function are not clear. Accordingly, the proposed study aims to investigate effects of probiotic beverage consumption on changes in behavioral and biological measures of cognition and stress among adults.
Interventions
OTHERLactose Free 1% Milk
isocaloric study treatment containing lactose free 1% milk consumed once daily over 4-5 weeks as a control.
OTHERProbiotic Treatment
Probiotic treatment, consumed once daily, over 4-5 weeks.
Sponsors
University of Illinois at Urbana-Champaign
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Intervention model description
Participants will pass through 2 arms, control and probiotic, in a randomized, counter-balanced order.
Eligibility
Sex/Gender
ALL
Age
25 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Males and females * Between the ages of 25-45 years at the time of consent * BMI ≥18.5 kg/m2 * Normal or corrected-to-normal vision based on the minimal 20/20 standard in order to complete the cognitive task. * Ability to drop-off fecal sample within 15 minutes of defecation
Exclusion criteria
* Current pregnancy or lactation * Tobacco use * Dairy allergy or intolerance * Prior diagnosis of metabolic and gastrointestinal disease (cardiovascular disease and type 1 or type 2 diabetes, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers, hepatitis, HIV, cancer, etc.) * Prior diagnosis of cognitive or physical disability, including ADHD, severe asthma, epilepsy, chronic kidney disease * Use of any anti-psychotic, anti-depressant, anti-anxiety, or ADD/ADHD medications * Use of medications that alter normal bowel function and metabolism (e.g., recent antibiotic use, laxatives, enemas, anti-diarrheal agents, narcotics, antacids, antispasmodics, diuretics, anticonvulsants). * Prior malabsorptive bariatric surgery (i.e. gastric bypass, sleeve gastrectomy) or restrictive bariatric surgery (i.e. adjustable gastric band) within the past 2 years.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in cortisol as a biomarker of stress | 4-5 weeks | The effects of probiotic consumption on biomarkers of stress |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in fecal microbiota populations | 4-5 weeks | The effects of probiotic consumption on fecal microbiota |
Other
| Measure | Time frame | Description |
|---|---|---|
| Changes in cognition | 4-5 weeks | The effects of probioticconsumption on cognition |
Countries
United States
Outcome results
None listed