Congenital Diaphragmatic Hernia
Conditions
Brief summary
To determine the appropriate volume (size) of ventilator breath during volume-targetted ventilation for infants born with congenital diaphragmatic hernia.
Interventions
DEVICEMeasurement of PTPdi
Insertion of pressure transducer catheter to measure gastic and oesophadgeal pressures for calculation of PTPdi
DEVICETTV at 4ml/kg
Provision of targetted tidal volume of 4ml/kg
DEVICETTV at 5ml/kg
Provision of targetted tidal volume of 5ml/kg
DEVICETTV at 6ml/kg
Provision of targetted tidal volume of 6ml/kg
Sponsors
King's College Hospital NHS Trust
King's College London
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 6 Months
Healthy volunteers
No
Inclusion criteria
* Congenital diaphragmatic hernia - post-operative Mechanically ventilated Born at \>34/40
Exclusion criteria
* neuromuscular blockade contraindications to NG/OG tube insertion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Pressure Time Product of the diaphragm (PTPdi) at different levels of targetted tidal volume | 3 hours | PTPdi will be measured at each level of tidal volume. The outcome measure is the change in PTPdi. |
Countries
United Kingdom
Contacts
Primary ContactKatie Hunt, MA, MBBS
Outcome results
None listed