Agitation, Postoperative Pain
Conditions
Brief summary
ASA I-II 3-12 years old children participated to this study. All Participants will divide into the three groups. In Groups I, 2,5 mg/kg propofol and 0,5 mg/kg ketamine will apply at anaesthesia induction. General anaesthesia will be performed with 5/1 ratio of ketamine-propofol mixture with %67 of Mcfarlan dose regiment. In Groups II, 2,75 mg/kg propofol and 0,41 mg/kg ketamine will apply at anaesthesia induction. General anaesthesia will be performed with 6,7/1 ratio of ketamine-propofol mixture with %80 of Mcfarlan dose regiment. In Groups III, 3 mg/kg propofol and 0,3 mg/kg ketamine will apply at anaesthesia induction. General anaesthesia will be performed with 10/1 ratio of ketamine-propofol mixture with %90 of Mcfarlan dose regiment. After than surgical operation recovery time, PAED scores, FLACC scores, Staying time in PACU will be recorded. These data will be evaluated with statistically.
Detailed description
ASA I-II, 3-12 years old children who will operate due to tonsillectomy and adenoidectomy. will be participated in to this study. All Participants will divide into the three groups. In Groups I, 2,5 mg/kg propofol and 0,5 mg/kg ketamine will apply at anaesthesia induction. General anaesthesia will be performed with 5/1 ratio of ketamine-propofol mixture with %67 of Mcfarlan dose regiment. In Groups II, 2,75 mg/kg propofol and 0,41 mg/kg ketamine will apply at anaesthesia induction. General anaesthesia will be performed with 6,7/1 ratio of ketamine-propofol mixture with %80 of Mcfarlan dose regiment. In Groups III, 3 mg/kg propofol and 0,3 mg/kg ketamine will apply at anaesthesia induction. General anaesthesia will be performed with 10/1 ratio of ketamine-propofol mixture with %90 of Mcfarlan dose regiment. McFarlan dose regiments include 15 mg/kg/h infusion during 15 minutes, 13 mg/kg/h infusion during second 15 minutes, 11 mg/kg/h infusion from 30 to 60 minutes, 10 mg/kg/h from 1 to 2 h. Anaesthesia dept will be detect with BIS monitoring during operation. After than surgical operation recovery time, PAED scores, FLACC scores, staying time in PACU and extubation time will be record. At the end of the study, these data will be evaluated with statistically.
Interventions
DRUGKetamine-propofol mixture
Ratio of Ketamine-propofol mixture will be compare for every groups.
Sponsors
Cukurova University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
3 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
* ASA I-II children * Children who will be performed to adenoidectomy and tonsillectomy surgical operations
Exclusion criteria
* ASA III-IV children * Patients over the age of 13
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PAED(Paediatric Anaesthesia Emergence Delirium) Scores Evaluation | During 1 hour at post operative period | All patients will be evaluate with PAED scores at PACU during first 1 hour |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Anaesthesia depth assessed using the Bispectral Index (BIS) | During peroperative period. | All Patients will monitored with BIS monitoring during operation. |
| Extubation time | time from injection of reversal to extubation, through patient extubated | At the end of the surgery, time from injection of reversal to extubation |
| FLACC(Face, leg movement, activity, craying, consolability) | During 1 hour at post operative period | All patients will be evaluate with FLACC scores at PACU during first 1 hour |
Countries
Turkey (Türkiye)
Outcome results
None listed