Study COFLORES

Study COFLORES :Imaging of Coronary Reserve Without Tracers

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02848703

Enrollment

Registered

2016-07-28

Start date

2016-07-26

Completion date

2022-10-27

Last updated

2022-11-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Perfusion

Brief summary

Myocardial perfusion is a major parameter characterizing the status of capillary circulation of the myocardium. Its quantification is possible using Magnetic Resonance Imaging (MRI) during the 1st pass of a contrast agent through the capillary system. This technique is radiation-free, but it is difficult to repeat measurements during a single exam. Also, a number of patients suffering from cardiac disease cannot receive contrast agent injections. The investigators have developed a totally non-invasive approach for quantifying myocardial perfusion. It is based on the magnetic labeling of arterial spins. Flowing into the capillaries (Arterial spin labeling, ASL). Goal : The major goal of this research protocol is to validate a totally non-invasive method of myocardial blood flow quantification using MRI without contrast agent injection

Interventions

DEVICEMagnetic Resonance Imaging (MRI)

DEVICEphosphorus-31 Magnetic Resonance Spectroscopy

DEVICEsodium-23 MRI

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* People having no heart disease or treatment referred to cardiology * People having no cons -indications to MRI * People having no cons -indications to gadolinium ; * People not wearing implantable devices * People not wearing metallic foreign bodies or risk (eg . Business of steel, etc .. ) * People having no cardiovascular risk factor * Person subject to the social security scheme * Nobody agreeing to participate in the study and who signed the informed consent

Exclusion criteria

* Refusal to go spontaneous or MRI because of claustrophobia important * Trouble rhythm making MRI uninterpretable

Design outcomes

Primary

Measure	Time frame	Description
Myocardial perfusion	1day	MRI based on the magnetic labeling of arterial spins

Secondary

Measure	Time frame	Description
the myocardial energetic status	1day	using phosphorus-31 Magnetic Resonance Spectroscopy
the myocardial sodium	1day	using sodium-23 MRI

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026