Alzheimer's Disease, Mild Cognitive Impairment
Conditions
Keywords
Mild cognitive impairment, Cognitive rehabilitation, Cognitive therapy, Alzheimer's disease, Memory enhancement, Categorical language fluency
Brief summary
The purpose of this study is to examine therapeutic efficacy of categorical language fluency smartphone game application in mild cognitive impairment and mild Alzheimer's dementia.
Detailed description
The Categorical Language Fluency Smartphone Game Application was developed based on the semantic distance training, which was effective in improving categorical language fluency of mild cognitive impairment and mild Alzheimer's dementia. 10 patients with mild cognitive impairment and another 10 patients with mild Alzheimer's dementia were recruited to examine therapeutic efficacy of the application.
Interventions
DEVICECategorical Language Fluency Smartphone Application
4 weeks' training
Sponsors
Seoul National University
Ministry of Science and ICT, Republic of Korea
Seoul National University Bundang Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
55 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Aged above 55 * Confirmed literacy * Diagnosed to mild cognitive impairment by International Working Group on Mild Cognitive Impairment and Clinical Dementia Rating(CDR) of 0 or 0.5. * Diagnosed to possible or probable Alzheimer's dementia by NINCDS-ADRDA and Clinical Dementia Rating(CDR) of 1 or below.
Exclusion criteria
* Evidence of delirium, confusion * Any neurological conditions causing cognitive decline such as Parkinson's disease, brain hemorrhage, brain tumor, normal pressure hydrocephalus * Evidence of severe cerebrovascular pathology * History of loss-of-consciousness over 1 hour due to head trauma or repetitive head trauma of mild severity * History of substance abuse or dependence such as alcohol * Presence of depressive symptoms that could influence cognitive function * Presence of medical comorbidities that could result in cognitive decline
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Application usage log | 4-weeks treatment | Log to assess compliance of participant(by describing frequency and duration of training by using application) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Subjective Memory Complaint Questionnaire | after 4-weeks treatment | to evaluate efficacy of application |
| Geriatric Depression Scale | after 4-weeks treatment | to evaluate efficacy of application |
| Korean version of MMSE for dementia screening | after 4-weeks treatment | to evaluate efficacy of application |
Outcome results
None listed