Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Periodontal Disease

The Levels of Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Gingival Crevicular Fluid in Periodontal Disease and Health

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02848378

Enrollment

Registered

2016-07-28

Start date

2014-05-31

Completion date

2015-04-30

Last updated

2016-07-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation, Periodontal Disease

Keywords

Advanced Oxidation Protein Products, Gingival crevicular fluid, Monocyte chemoattractant protein-1, Periodontal Disease

Brief summary

This study investigates the levels of advanced oxidation protein product and monocyte chemoattractant protein-1 in gingival crevicular fluid in periodontal disease and health. 25 participants with chronic periodontitis, 25 participants with gingivitis and 25 periodontally healthy subjects are included into this study. In each participant, four sites are identified for gingival crevicular fluid samples.

Detailed description

Oxidative stress is the disequilibrium between the formation of free radicals and antioxidant defense mechanisms via damaging cellular macromolecules (DNA, protein, lipid, etc..) which are susceptible to oxidative damage. Advanced oxidation protein product is identified as a new marker of protein oxidation. Monocyte chemoattractant protein-1 is a major chemoattractant for lymphocytes, monocytes and macrophages.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 66 Years

Healthy volunteers

Yes

Inclusion criteria

* Clinical diagnosis of chronic periodontitis and gingivitis

Exclusion criteria

* Systemic illnesses * Any medications known to affect the periodontium * Pregnancy and lactation

Design outcomes

Primary

Measure	Time frame
Advanced oxidation protein product (nmol)	Before periodontal treatment

Secondary

Measure	Time frame
The probing depth (mm), clinical attachment level (mm), plaque index scores (0-3) and gingival index scores (0-3)	Before periodontal treatment
Monocyte chemoattractant protein-1(pg)	Before periodontal treatment

Outcome results