Hypogonadism
Conditions
Brief summary
Sexual steroids administered to supra-physiological doses are likely to change the carbohydrate and lipid metabolism. Investigators propose to study in 12 hypogonadal men hypogonadotropic or hypergonadotropic treated with aromatase inhibitor, the respective effects of estradiol, testosterone or both steroids administered in a cross-over Latin squares plan on insulin sensitivity measured by the reference method of the hyperinsulinemic euglycemic clamp.
Interventions
BIOLOGICALEstradiol (Insulin sensitivity)
BIOLOGICALTestosterone (Insulin sensitivity)
Sponsors
University Hospital, Caen
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Hypogonadism hypogonadotropic or hypergonadotropic * Man aged 18-60 years * BMI between 18 and 27.
Exclusion criteria
* Other ante-pituitary deficiency * Chronic treatment modifying carbohydrate metabolism (thiazides, beta 2 mimetics, steroids ...) * Diabetes * Obesity diffuse or android * Hemochromatosis * osteoporosis * chronic diseases * neoplasia * High blood pressure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GIR (glucose infusion rate) during euglycemic hyperinsulinemic clamp | change between baseline and after 4 weeks of treatments |
Countries
France
Outcome results
None listed