Depression
Conditions
Keywords
resistant depression, inflammation
Brief summary
This study focuses on blood inflammatory markers (pro-inflammatory cytokines, anti-inflammatory cytokines, monocytes costimulation molecules) in patients with resistant unipolar depression in comparison with non-resistant unipolar depressed patients.
Interventions
PROCEDUREblood sample
blood sample for concentration levels of inflammatory markers
BEHAVIORALpsychometric scales
Mini international interview MADRS, C-SSRS, QIDS-SR, BIS-10, BDHI, BART, ERD
Sponsors
Centre Hospitalier Universitaire de Besancon
Study design
Allocation
NON_RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
SCREENING
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* group 1: Patients with resistant MDD (at least 2 failed treatments for the current episode) ,current treatment with IRS or IRSNA, * group 2: patients with MDD remission after response to an antidepressant treatment.
Exclusion criteria
* comorbid somatic or psychiatric disorders: chronic or acute inflammatory diseases, previous treatment with brain stimulation for the current episode, legal protection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| plasmatic concentration of Interleukin 6 | at patient inclusion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| concentration of proinflammatory cytokine | at patient inclusion | Expression intensity of monocytes costimulation molecules |
| concentration of antiinflammatory cytokine | at patient inclusion | — |
| functional polymorphisms of expression genes of inflammatory proteins | at patient inclusion | — |
| plasmatic concentration of Retinoid X receptor signaling pathway | at patient inclusion | — |
| Expression rate of monocytes costimulation molecules | at patient inclusion | — |
Countries
France
Contacts
Primary ContactEmmanuel Haffen, MD PhD
Backup ContactJulie Monnin, PhD
Outcome results
None listed