Healthy Subjects
Conditions
Brief summary
the aim of this study are to explore the characteristics of mean airway pressure, oscillatory amplitude and power spectral density (PSD) of oscillatory airway pressure that generate by various loaded and flow rate during expiration and inspiration in healthy subjects and to explore the best loaded and flow rate for airway secretion clearance using the BreatheMAX® device
Detailed description
For inspiratory group, the resistive load 3, 4, 5, 6 and 7 cm H2O were test with three flow rate: 0.2, 0.4, and 0.6 L/sec in each load. In each flow rate, the subjects were instructed to inspire as deeply as possible with steady flow rate for 3 seconds with end-inspiratory pause for 2-3 seconds through the inspiratory circuit and follow by passive exhalation. For expiratory group, the resistive load and flow rate were test similar inspiratory group. In each flow rate, the subjects were instructed to inspire as deeply as possible through the nose with end-inspiratory pause for 2-3 seconds and partially forced exhalation with reach to 1/3 of expiratory reserve volume (ERV) for at least 3 seconds through expiratory circuit
Interventions
Sponsors
Khon Kaen University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* the healthy subjects * able to breathe against resistive load with the BreatheMAX device * good conscious and cooperation
Exclusion criteria
\- fever
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PSD of oscillatory airway pressure | 5 seconds during inspiration and expiration testing period |
Secondary
| Measure | Time frame |
|---|---|
| mean airway pressure | 5 seconds during inspiration and expiration testing period |
| oscillatory amplitude | 5 seconds during inspiration and expiration testing period |
Countries
Thailand
Outcome results
None listed