Neuromuscular Disease
Conditions
Keywords
cough help, mechanical insufflation, mechanical ventilation, neuromuscular diseases, peak cough flow
Brief summary
The purpose of the study is to compare the the efficacy and tolerance of 2 cough assistance techniques requiring no equipment other than the volumetric fan. The two methods are air-stacking and hyperinflation . The study is a Cross-over, monocentric and open label study
Detailed description
Primary outcome : Peak Expiratory Flow (PEF)
Interventions
DEVICEincrease of cough peak flow (Astral ventilator)
instrumental increase of cough peak flow with a ventilator by hyper-insufflation and with air stacking method
Sponsors
ResMed
Centre d'Investigation Clinique et Technologique 805
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age\>18 years, neuromuscular disease, * restrictive syndrome and/or cough peak flow \< 270.l/mn and/or maximal expiratory pressure \< 40 cm HO2, * patient under non invasive ventilation * steady state for at least one month * written consent form given
Exclusion criteria
* bronchial congestion * hemodynamic instability * previous pneumothorax or emphysema bubbles * Major bulbar dysfunction * plan of legal protection * pregnant or breastfeeding women * no affiliation to a social security scheme
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peak cough flow | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| effective cough time | 1 year |
| inspired volume | 1 year |
| maximal expired volume | 1 year |
| respiratory comfort (Visual Analog Scale) | 1 year |
| subjective patient's effectiveness of cough (Visual Analog Scale) | 1 year |
Countries
France
Outcome results
None listed