Factors Associated With Complications of Cervical Necrotizing Fasciitis

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02847234

Enrollment

350

Registered

2016-07-28

Start date

2015-01-31

Completion date

2016-12-31

Last updated

2016-07-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical Necrotizing Fasciitis

Keywords

Cervical necrotizing fasciitis, mediastinitis

Brief summary

Cervical necrotizing fasciitis (CNF) is a rare but severe complication of pharyngeal or dental infections. The infection can rapidly descend into the mediastinum and lead to a life-threatening prognosis. Treatment consists of a multidisciplinary approach in intensive care with radiologist and with early and repeated surgical debridement. Anti-inflammatory drugs have been incriminated by authors in the development of necrotizing fasciitis. Recently, a single-center study demonstrated that pharyngeal source of CNF and oral glucocorticoid intake before admission was associated with the occurrence of mediastinitis. The aim of the study is to assess the incidence and factors associated with CNF complications, in particular mediastinitis. Secondary outcome is to describe patient characteristics, medical and surgical management. Methods: A retrospective, observational, non-interventional multicentre study is conducted in nine intensive care units in France from January 2005 to December 2016.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

\- Patient admitted in ICU for management of cervical necrotizing fasciitis between 2005 and 2016.

Exclusion criteria

* Patients admitted in ICU for management of cervical abscess without cervical necrotizing fasciitis * Age \< 18 years

Design outcomes

Primary

Measure	Time frame	Description
incidence of mediastinitis	At the entry in ICU (Day 1)	Computed tomography (CT) is performed at admission. Mediastinitis is described on CT finding.

Secondary

Measure	Time frame	Description
factors associated with mediastinitis	At the entry in ICU (Day 1)	Computed tomography (CT) is performed at admission. Mediastinitis is described on CT finding.

Countries

France

Contacts

Primary ContactThomas Rimmelé, MD PhD

thomas.rimmele@chu-lyon.fr(0)4 72 11 69 88

Backup ContactMyrtille Fouché, Resident

myrtille_fouche@hotmail.com(0)6 13 78 24 54

Outcome results