Cough Peak Flow for Extubation Prediction

Assessing Cough Peak Flow (CPF) Using Ventilator built-in Flow-meter to Predict Extubation Success: A Single Centre Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02847221

Acronym

CPF

Enrollment

Registered

2016-07-28

Start date

2014-11-30

Completion date

2015-11-30

Last updated

2016-07-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Extubation in ICU Patients

Keywords

cough peak flow, scheduled weaning trial, scheduled extubation, prognosis

Brief summary

Successful weaning from mechanical ventilation in ICU patients depends on patient ability to breathe spontaneously and on cough efficiency. Previous studies found that cough peak flow (CPF) at 60 L/min threshold predicted extubation failure. These studies measured CPF using a dedicated flow-meter that required patient disconnection from the ventilator, limiting the generalizability of this procedure. This study aimed to predict extubation outcome in a consecutive series of patients by measuring CPF from the ventilator flow-meter. CPF measurements were done by freezing ventilator screen and scrolling the cursor to the maximal value of CPF during expiration and Tidal Volume (TV) in preceding inspiration. The objective was to assess the performance of CPF to predict early extubation outcome.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \> 18 years * Intubation \> 24h * Eligible for scheduled weaning trial and then scheduled extubation * Mechanical ventilation from Evita XL ventilator (Dräger, Germany) * Patient's agreement to participate

Exclusion criteria

\- Withdrawal decision of life supporting care

Design outcomes

Primary

Measure	Time frame	Description
Early extubation success rate (EES rate)	48 hours	Defining a relation between the CPF/TV ratio before extubation and early extubation success rate

Secondary

Measure	Time frame	Description
Scheduled weaning trial success rate	48 hours	Defining a relation between the CPF/TV ratio before weaning trial and scheduled weaning trial success rate

Countries

France

Outcome results