Intractable Epilepsy
Conditions
Brief summary
To determine the utility of diffusion tensor magnetic resonance imaging in the preoperative workup of children with intractable epilepsy referred for surgery.
Detailed description
To determine if diffusion tensor and functional connectivity magnetic resonance imaging helpful to better understand and diagnose intractable epilepsy in children. All enrolled children will undergo standard preoperative and postoperative MRI imaging, plus a 15 minute set of functional connectivity and diffusion tensor sequence with no additional sedation. This imaging data will be stripped of identifiers and be processed to provide both quantitative analysis, resting state functional connectivity changes and three dimensional modeling of white matter tracts adjacent to epileptogenic foci. This study is being done to determine if diffusion tensor and functional connectivity magnetic resonance imaging are helpful to better understand and diagnose intractable epilepsy in children.
Interventions
PROCEDUREObservation
Observation of MRI changes in subjects
Sponsors
The University of Texas Health Science Center, Houston
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
0 Days to 18 Years
Healthy volunteers
No
Inclusion criteria
* Children diagnosis with Intractable Epilepsy
Exclusion criteria
* No Intractable Epilepsy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of participants with seizure outcome as determined by Engel | 5 years |
Countries
United States
Contacts
Primary ContactManish N Shah, M.D.
Backup ContactBangning L Yu, R.N., PhD
Outcome results
None listed