Multiple Sclerosis
Conditions
Brief summary
The purpose of this study is to better characterize the fluctuations in multiple sclerosis symptoms and their relationship to medications, to length/extent of disease, and to a variety of physiologic measures.
Interventions
OTHERPersonal history of multiple sclerosis
Participants will be stratified into one of four cohorts based on their experience (or lack of experience) with the three major forms of multiple sclerosis.
Sponsors
Duke University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Be at least 18 years old * Live in the United States of America * Read/write in English
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in perceived fatigue severity (self-report) as recorded by symptom diary | Every 24 hours through study completion, an average of 6 months | — |
| Change in perceived cognitive impairment (self-report) as recorded by symptom diary | Every 24 hours through study completion, an average of 6 months | Severity of cognitive impairment experienced from multiple sclerosis |
| Change in perceived depression or anxiety severity (self-report) as recorded by symptom diary | Every 24 hours through study completion, an average of 6 months | Severity of any mood disorders experienced from multiple sclerosis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in perceived sensory disturbance (self-report) as recorded by symptom diary | Every 24 hours through study completion, an average of 6 months | — |
| Change in perceived vertigo severity (self-report) as recorded by symptom diary | Every 24 hours through study completion, an average of 6 months | — |
| Change in perceived dysarthria severity (self-report) as recorded by symptom diary | Every 24 hours through study completion, an average of 6 months | — |
| Change in pain (self-report) as recorded by symptom diary | Every 24 hours through study completion, an average of 6 months | — |
| Change in perceived walking instability (self-report) as recorded by symptom diary | Every 24 hours through study completion, an average of 6 months | — |
| Change in medication adherence (self-report) as recorded by medication diary | Every 24 hours through study completion, an average of 6 months | — |
| Change in self-efficacy (self-report) as determined by the Multiple Sclerosis self-efficacy scale (survey instrument) | every three months, through study completion (an average of 6 months) | — |
| Change in Multiple Sclerosis Quality of Life Inventory | prompted based on the app user's responses on the daily surveys, up to 6 months | The Multiple Sclerosis Quality of Life Inventory surveys are prompted based on the app user's responses on the daily surveys. |
| Change in sleep quality as recorded by app-linked wearable device | Every 24 hours through study completion, an average of 6 months | — |
| Change in perceived vision difficulties (self-report) as recorded by symptom diary | Every 24 hours through study completion, an average of 6 months | — |
| Change in perceived Bowel/Bladder dysfunction (self-report) as recorded by symptom diary | Every 24 hours through study completion, an average of 6 months | Severity of bowel/bladder dysfunction experienced from multiple sclerosis |
Countries
United States
Outcome results
None listed