Infertility
Conditions
Keywords
IVF
Brief summary
Comparison between usage of Sildenafil citrate with estradiol valerate or estradiol valerate alone in endometrial preparation and outcome of frozen-thawed embryo transfer cycles.
Interventions
DRUGSildenafil citrate
DRUGestradiol valerate
Sponsors
Omar Ahmed El Sayed Saad
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 37 Years
Healthy volunteers
No
Inclusion criteria
* all cases have at least 2 good quality blastocysts available for transfer
Exclusion criteria
* uterine structural abnormalities * advanced uterine disease * hydrosalpinx and pyosalpinx
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| endometrial pattern | starting from 8th day till 12th day of the menstrual cycle | Endometrial pattern will be trilaminar or bilaminar after it's preparation with estradiol valerate alone or estradiol valerate and sildenafil citrate. Endometrial pattern will be estimated by transvaginal ultrasonography for trilaminar pattern every other day from 8th day till 12th day of the menstrual cycle. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| endometrial thickness | starting from 8th day till 12th day of menstrual cycle | Endometrial thickness will be estimated by transvaginal ultrasonography after it's preparation with estradiol valerate alone or estradiol valerate and sildenafil citrate for thickness 8 mm or more every other day from 8th day till 12th day of the menstrual cycle. |
| biochemical pregnancy test | 2 weeks after embryo transfer | Serum B,human chorionic gonadotropin subunit will be measured 2 weeks after embryo transfer which will be positive when it's level exceeds 5 milli international unit /milli litre in patient's serum. |
Outcome results
None listed