Hemodynamic Response to Intubation

The Effects of Preintubation Esmolol and and Dexmedotimidine on Ischmeia Modified Albumin Levels

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02844894

Enrollment

Registered

2016-07-26

Start date

2016-06-30

Completion date

2016-09-30

Last updated

2016-07-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intubation

Keywords

intubation, ischemia modified albumine, dexmedetomidine, esmolol

Brief summary

This study investigates the effects of dexmedetomidine and esmolol given intravenously before intubation on sympathetic response caused by intubation itself. Half the patients will recevice dexmedetomidine and the other half will receive dexmedetomidine. Ischemia modified albumine levels will be measured

Interventions

DRUGDexmedetomidine

DRUGEsmolol

DRUGPlacebo

normal saline

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Patients undergoing elective surgery under general anesthesia

Exclusion criteria

* Patient refusal * Morbid obesity (BMI\>30) * Advanced systemic disease * Hypoalbumiemia * beta-blocker usage * Anticipated difficult ventilation and/or intubation

Design outcomes

Primary

Measure	Time frame	Description
ischemia modified albumine	10 minutes after endotracheal intubation	ischemia modified albumine levels will be measured as a response to intubation

Countries

Turkey (Türkiye)

Contacts

Primary ContactPerihan Ekmekçi, Ass Prof

erdogduperi@gmail.com+903122044000

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026