Coronary Artery Disease
Conditions
Keywords
Myocardial perfusion imaging, Single-Photon Emission Computer-Assisted Tomography
Brief summary
New CZT-based SPECT cameras are potentially capable of dynamic 3-D acquisition. Preliminary results suggested that dynamic acquisitions could allow the assessment of myocardial flow reserve using 99mTc-labelled perfusion tracers. The Flow-Heart study will assess the feasibility of myocardial flow reserve measurement by means of 99mTc-DTPA dynamic cardiac SPECT in 20 patients.
Interventions
OTHERCardiac SPECT
3-D dynamic acquisition of cardiac SPECT at rest and after pharmacological stress
Sponsors
University Hospital, Caen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age over 18 years * Patient clinically stable with known or suspected coronary disease * Patient referred to Caen University Hospital for a myocardial perfusion SPECT * Patient who accept to undergo subsequent additional cardiac dynamic SPECT using 99mTc-DTPA at rest and during pharmacological stress * Informed consent dated and signed * Affiliation to a social security system
Exclusion criteria
* Contraindication to dipyridamole (asthma, chronic obstructive pulmonary disease , pulmonary hypertension) * History of poor tolerance of dipyridamole injection * Cardiac arrhythmia (atrial fibrillation or frequent premature ventricular complex) * Left bundle branch block, cardiac pacemaker, or implantable automatic defibrillator * Recent history of myocardial infarction or unstable angina * Pregnancy or lactating women * Known obstructive renal or urinary disease * Age under 18 years or guardianship * Patient with an acute coronary syndrome or a coronary revascularization occurring between the conventional perfusion SPECT and the subsequent 99mTc-DTPA dynamic SPECT
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility of myocardial flow reserve assessment by dynamic cardiac SPECT using a CZT camera and 99mTc-DTPA | Within one month after a conventional myocardial perfusion SPECT |
Contacts
Primary ContactAlain Manrique, MD, PhD
Backup ContactDenis Agostini, MD, PhD
Outcome results
None listed