Epilepsy
Conditions
Keywords
Epilepsy, Surgery candidate, EEG's Signal
Brief summary
Epilepsy is a devastating chronic disease due to multiple causes that affect close to 50% of the world's population. Although effective, epilepsy surgery fails in many cases, the percentage of patients free from crisis on a long term (≥ 5 years) varies from 27% to 66% according to the kind of epilepsy. It is in this context that EPISTIM is interesting, and its aims isb a better electrophysiology delimiting of cortical networks that imply the genesis of seizures with the aim to improove surgery results. This study will rely on the intracerebral records and on corticales electrical stimulation as they are currently routinely used by epileptic patients candidates for surgery.
Interventions
OTHERFunctional stereotaxic exploration
Visual analysis : in order to define the level of cortical resections. Epileptogenic maps : calculated for each crisis and for all crisis in general. Connectivity maps : calculated for each site stimulated at low-frequency. Post-operative evaluation : in order to assess the extent of resection.
Sponsors
University Hospital, Grenoble
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
5 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
: * Patient from 5 to 65 years (L1121-7 L1122 2 CSP), including legally protected or unable to give his consent (L1121-8 CSP). * Written approval of inclusion in the study from the patient or his legal representative. * Patients with partial Epilepsy Drug Resistant , justifying a SEEG exploration.
Exclusion criteria
: * Patient under 5 years. * Patient over 65 years. * Pregnant or breastfeeeding women (L1121-5 CSP). * Patient deprived of liberty as a result of a judicial or administrative decision (L1121-6 CSP). * Patients over 18 years unable to give their free consent and not subject to a legal protection order.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visual analysis | up to one hour | Visual analysis : in order to define the level of cortical resections. |
| Epileptogenic maps | up to 10 min | Epileptogenic maps : calculated for each crisis and for all crisis in general. |
| Connectivity maps | up to 10 min | Connectivity maps : calculated for each site stimulated at low-frequency. |
| MRI | up to one hour | Post-operative evaluation : in order to assess the extent of resection. MRI : 3D-T1 |
Countries
France
Contacts
Primary ContactPhilippe Kahane, Professor
Backup ContactLorella Minotti, Hospital Practitioner
Outcome results
None listed