Restrictive Lung Disease
Conditions
Brief summary
The study aims to investigate the effect of dexmedetomidine on oxygenation and lung mechanics in morbidly obese patients
Detailed description
The patients of interest are morbid obese patients scheduled for bariatric surgery. Dexmeditomidine will be infused intraoperatively after induction of anesthesia. lung mechanics (dead space and compliance) as well as oxygenation (PF ratio) will be monitored intraoperatively and postoperatively
Interventions
DRUGDexmedetomidine
Dexmedetomidine infusion was previously reported to improve oxygenation and lung dynamics in patients with obstructive lung diseases. In our study we are going to investigate its effect on oxygenation and lung dynamics in restrictive lung disease
DRUGNormal saline
Normal saline
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
\- Morbid obese (body mass index \> 40) with documented restrictive lung disease scheduled to bariatric operation.
Exclusion criteria
* Heart failure * ِِِِArrhythmia * Heart block * Severe liver or kidney impairment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oxygenation | 2 hours | assessed by P/F ratio |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lung mechanics | 2 hours | lung compliance and dead space |
| arterial blood pressure | 2 hours | arterial blood pressure measured in mmHg |
| plateau airway pressure | 2 hours | plateau airway pressure measured in cmH2o |
| heart rate | 2 hours | number of heart beats per minute |
Countries
Egypt
Outcome results
None listed