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Evaluation of Corrected Carotid Artery Flow Time as a Predictor of Fluid Responsiveness in Spontaneous Breathing Patients

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02843477
Enrollment
54
Registered
2016-07-25
Start date
2016-08-09
Completion date
2017-02-28
Last updated
2018-07-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Tumor

Brief summary

It is still challenging to assess intravascular volume status in spontaneously breathing patients. Recently, the measurement of corrected flow time in carotid artery was introduced as quite useful, simple and noninvasive for the evaluation of circulating blood volume change. The aim of this study is to evaluate whether corrected carotid artery flow time as determined by ultrasonography can be a predictor of fluid responsiveness in spontaneously breathing patients before induction of general anesthesia.

Interventions

Corrected carotid artery flow time is measured using 10-5 MHz linear probe on a portable ultrasound machine. On the two-dimensional image, the optimal image of the long-axis view is obtained at the left common carotid artery. The sample volume is placed on the center of the lumen, 2 cm proximal to the bulb, and a pulsed wave Doppler examination was performed while the Doppler beams were adjusted to ensure \< 60° of angle for the best signal. Then, cardiac cycle time and carotid flow time is measured. Carotid flow time is measured between the upstroke of the flow tracing and the dicrotic notch, and it is corrected for pulse rate by dividing flow time by the square root of the cardiac cycle time to calculate corrected carotid artery flow time (flow time/√cycle time).

Sponsors

Yonsei University
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
19 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* adult patients (19-80 years of age) who were scheduled to undergo elective neurosurgery for brain tumor

Exclusion criteria

* BMI \> 35 or \< 15 kg/m2 * the presence of carotid artery stenosis \> 50% * systolic blood pressure \> 160 mmHg * cardiac rhythm other than sinus * intracardiac shunt 6. valvular heart disease * a left ventricular ejection fraction of \< 50% * right ventricular dysfunction 9 * chronic obstructive pulmonary disease * pulmonary hypertension * chronic kidney disease (eGFR \< 60 mL/min/1.73m2) * pregnancy

Design outcomes

Primary

MeasureTime frameDescription
ultrasonographic measurement of corrected flow time in carotid arteryright before fluid loadingThe ultrasonographic measurement of corrected flow time in carotid artery will be performed before fluid loading.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026