Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02842593

Enrollment

Registered

2016-07-25

Start date

2014-09-30

Completion date

2016-08-31

Last updated

2017-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Weight-Lifting Exercise Program

Brief summary

This study evaluates the effects of two types of resistance exercise training (higher-repetition, lower load vs lower-repetition, higher load vs control) on regional and local measures of arterial stiffness in trained young men.

Interventions

BEHAVIORALLower-repetition, heavier-load

8-12 reps/set at \ 80% 1 repetition maximum

BEHAVIORALHigher-repetition, lighter-load

20-25 reps/set at \ 30% 1 repetition maximum

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Male * Aged 18-30 years old * Non-obese (Body mass index less than 30 kg/m2) * Non-smoker * Healthy based on questionnaire responses * Resistance trained (Resistance training \> 2 times per week for 2 years, minimum 1 lower body exercise session per week)

Exclusion criteria

* Allergies to milk proteins (whey or casein) * Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires * Arthritic conditions * Individuals who consume any analgesic or anti-inflammatory drug(s), prescription or non- prescription, chronically will be excluded * A history of neuromuscular problems * Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).

Design outcomes

Primary

Measure	Time frame	Description
Carotid-femoral pulse wave velocity	12 weeks post exercise training	Assessed using applanation tonometry

Secondary

Measure	Time frame	Description
Common carotid artery distensibility	12 weeks post exercise training	Assessed using vascular ultrasound
Left ventricular mass	12 weeks post exercise training	Assessed using standard echocardiography

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026