Organ Protection
Conditions
Keywords
dexmedetomidine, sepsis, respiration
Brief summary
The purpose of this study is to assess the efficacy of dexmedetomidine on lung protection in patient with sepsis undergoing cleaning focus of infection.
Detailed description
Sepsis is one of the most common, life-threatening medical conditions and is frequently complicated by organ failures, especially lung injury. It is well accepted that inflammatory reaction is the major cause of lung injury. Dexmedetomidine (Dex) is a novel α2-adrenoceptor agonist that is primarily used in surgical anesthesia and conscious-sedation. Recently, animal studies have shown that Dex plays an anti-inflammatory role, while it is not known whether Dex possesses any lung protective functions in patients with sepsis. Therefore, the aim of this study is to investigate the efficacy of Dex on lung protection in patient with sepsis undergoing cleaning focus of infection.
Interventions
DRUGdexmedetomidine
receive a loading infusion of dexmedetomidine (1ug/kg) for 10min follow by a maintenance infusion (0.5ug/kg·h) continued until the end of the surgery
OTHERnormal saline
receive matching placebo (equal volume of normal saline)
Sponsors
General Hospital of Ningxia Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* The patients with sepsis requiring abdominal cleaning focus of infection * older than 18 years * American Society of Anesthesiologists (ASA) physical status II-IV.
Exclusion criteria
* Bradycardia * Atrioventricular block * Allergic to the drugs * A history of respiratory disease * Pregnancy or breast-feeding women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The Alveolar-Arterial Oxygen Difference | Before anesthesia | Arterial blood samples were sampled before anesthesia for the alveolar-arterial oxygen difference by using blood gas analyzer. |
| The Oxygenation Index | Before anesthesia | Arterial blood samples were sampled before anesthesia for the oxygenation index by using blood gas analyzer. |
| The Respiratory Index | Before anesthesia | Arterial blood samples were sampled before anesthesia for the respiratory index by using blood gas analyzer. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of tumor necrosis factor-α before anesthesia and after dexmedetomidine or placebo infusion instantly | Before anesthesia and at 3 minutes after the skin is sutured | Blood samples were sampled before anesthesia and at 3 minutes after the skin is sutured for the serum tumor necrosis factor-α，which were analyzed by using enzyme linked immunosorbent assay (ELISA). |
| Change of interleukin-1β before anesthesia and after dexmedetomidine or placebo infusion instantly | Before anesthesia and at 3 minutes after the skin is sutured | Blood samples were sampled before anesthesia and at 3 minutes after the skin is sutured for the interleukin-1β，which were analyzed by using enzyme linked immunosorbent assay (ELISA). |
| Change of the lactic acid before anesthesia and after dexmedetomidine or placebo infusion instantly | Before anesthesia and at 3 minutes after the skin is sutured | Arterial blood samples were sampled before anesthesia and at 3 minutes after the skin is sutured for the lactic acid by using blood gas analyzer. |
Countries
China
Contacts
Primary ContactMa Hanxiang
Backup ContactZhang Yonghai
Outcome results
None listed