Inappropriate Prescribing of Proton-pump Inhibitor is it Associated With the Burden of Comorbidities in Older Patients?

Inappropriate Prescribing of Proton-pump Inhibitor is it Associated With the Burden of Comorbidities in Older Patients Over 75 Years Old ?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02841852

Acronym

IPP SA

Enrollment

280

Registered

2016-07-22

Start date

2014-01-31

Completion date

2014-07-31

Last updated

2016-07-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Geriatric Disorder

Brief summary

Proton pump inhibitors (PPIs) are one of the most frequently prescribed classes of drugs in the world and the most effective drugs available to reduce gastric acid secretion. However, studies have shown that PPIs are not always prescribed with a clear indication. Indeed, between 25% and 86% of older individuals taking a PPI have been overprescribed these medications. In older patients, overprescribing of a PPI is associated with increases in morbidity, adverse drug events, hospitalization, and mortality. The hypothesis is that overprescription of PPIs is associated with the individual multimorbidities in older patients evaluated using the multimorbidities group criteria included in the CIRS. The aim of the present study was to establish a relationship between overprescribing of PPIs and multimorbidities in older patients.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

75 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients of 75 years or more * Patients hospitalized in geriatric short stay * Patients with an inhibitor therapy proton pump short geriatric entry * Patients who have given their written consent

Exclusion criteria

* Patients who have expressed their inability or refusal to sign an informed consent

Design outcomes

Primary

Measure	Time frame	Description
Burden of comorbidities	48 hours after the entry into acute geriatric medicine	Burden of comorbidities is assessed by the CIRS (Cumulative Illness Rating Scale)

Countries

France

Outcome results