Candidemia, Genetic Predisposition to Disease, Invasive Candidiasis
Conditions
Keywords
Gene Expression Profiling, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Drug Resistance, Fungal
Brief summary
This is a prospective case-control physiopathological study, which main objective is to determine the genetic host factors predisposing to candidemia. Secondary objectives are to develop new diagnosis tools using the biological collection, to describe and update epidemiology, to analyse the influence of genetic polymorphisms on prognosis.
Interventions
An analysis of the SNPs (single nucleotide polymorphism) of 25 candidate genes will be performed. This analysis will be completed by a genome wide association study.
Sponsors
Seventh Framework Programme
University of Lausanne Hospitals
University Hospital, Lille
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient older than 18 years. * Informed consent. * Positive blood culture with isolation of Candida sp.
Exclusion criteria
* No informed consent. * Patient younger than 18. * No insurance coverage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of the polymorphisms between the groups | In the 48-72 hours following the positive blood culture |
Countries
France
Outcome results
None listed