Kidney Neoplasms
Conditions
Brief summary
The purpose of this study is to determine if biopsy for non-neoplastic renal disease for patients with a small renal mass results in greater postoperative renal function than the current standard of care (no additional biopsy).
Interventions
PROCEDUREAdditional biopsy
• Patients in the experimental group receive the additional biopsy for non-neoplastic disease during the same procedure before the biopsy of the renal mass (with potential for direct benefit to the patient by revealing non-neoplastic renal disease).
Sponsors
University of Virginia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Age 18 or greater * Scheduled for renal biopsy as part of clinical care * Diagnosis of small renal mass (\< 4cm) based on imaging (CT, MRI, Ultrasound, or other) * Patient must provide written, informed consent for study procedures before randomization * Renal mass must be primarily solid (as opposed to cystic) in nature
Exclusion criteria
* Patients less than 18 years of age * Patients who are prisoners * Women who are pregnant-self reported * Patients with Bosniak 3 or 4 cystic renal masses * Patients with history of renal transplantation * Patients with eGFR less than 30-based on review of clinical labs * Patients on dialysis * Patients with bleeding disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| difference in change in glomerular filtration rate (GFR) | 6 months |
Outcome results
None listed