Tardive Dyskinesia
Conditions
Keywords
tardive dyskinesia., rTMS
Brief summary
The purpose of this study is to explore the therapeutic effect and mechanism of transcranial magnetic stimulation (rTMS) in the treatment of the tardive dyskinesia.
Detailed description
The study was a parallel control design trial for 2 weeks. Patients with schizophrenia were treated with 10-Hz rTMS on left motor cortex (added to the ongoing treatment). Clinical symptoms and MEP were assessment before and after rTMS treatment.
Interventions
DEVICERepetitive Transcranial Magnetic Stimulation
Stimulate the primary motor cortex for 2 weeks.
Sponsors
Shanghai Mental Health Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* The diagnosis of schizophrenia according to DSM-IV； * At least two item of Abnormal Involuntary Movement Scale（AIMS） must be 2 points or higher * these symptoms are not from Parkinson，tourette's syndrome,huntington disease * Signed an informed consent
Exclusion criteria
* rTMS contraindications: intracranial metal substance, with heart pacemakers and cochlear implants, intracranial pressure * patients to be diagnosed according to DSM-IV for substance abused, development delayed * current treatment with anticonvulsant acting drugs such as anticonvulsants, benzodiazepines * Acute risk of suicide and impulse * history of epileptic seizures or the presence of epileptic activity documented on the basis of EEG * pregnant and lactant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in motor evoked potential(MEP) | 2 times (Before treatment,immediately after treatment) |
| Change from baseline in Abnormal Involuntary Movement Scale(AIMS） | 2 times (Before treatment,immediately after treatment) |
Secondary
| Measure | Time frame |
|---|---|
| Change from baseline in intracortical facilitation(ICF） | 2 times (Before treatment,immediately after treatment) |
| Change from baseline in Simpson-Angus Scale（SAS） | 2 times (Before treatment,immediately after treatment) |
| Change from baseline in cortical silent period | 2 times (Before treatment,immediately after treatment) |
| Change from baseline in Positive and Negative Syndrome Scale（PANSS） | 2 times (Before treatment,immediately after treatment) |
| Change from baseline in clinical global impression (CGI) | 2 times (Before treatment,immediately after treatment) |
| Change from baseline in Barnes Akathisia Rating Scale（BARS） | 2 times (Before treatment,immediately after treatment) |
| Change from baseline in short interval intracortical inhibition(SICI） | 2 times (Before treatment,immediately after treatment) |
Countries
China
Contacts
Primary ContactDengtang Liu
Outcome results
None listed