Development of a New Neuroimaging Method Aimed to Differentiate Mnesic Abilities of Alzheimer and Depressed Patients

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02840045

Acronym

RIHANNA

Enrollment

Registered

2016-07-21

Start date

2015-02-20

Completion date

2018-08-20

Last updated

2017-08-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer Disease, Depression

Keywords

electroencephalography (EEG)

Brief summary

The purpose of this study is to use a new method to differentiate mnesic abilities of early alzheimer patients and patients with a depressive disorder. This method is based on the recording of cerebral activity while patients listen to familiar, unfamiliar and newly-learned music.

Interventions

DEVICEhigh-density electroencephalography

Musical stimulation during electroencephalography recording

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Being right-handed * recorded consent * For Alzheimer patients: Mini Mental Status Examination (MMSE) score \>= 18 * For patients with a depressive disorder : Major Depressive Disorder according to Diagnostic and Statistical Manual of Mental Disorders (DSM IV) and Montgomery-Asberg depression rating scale (MADRS) score \>= 25 * For healthy controls : no cognitive deficit, MADRS score \< 25, no depressive disorder according to DSM IV

Exclusion criteria

* Auditory deficit * contraindication to a high-density electroencephalography exam * refusal to participate in the study

Design outcomes

Primary

Measure	Time frame	Description
Amplitude of event-related potentials	day 1 for familiar and unfamiliar songs and day 14 for newly learned songs	Measurements of the amplitude of event-related potentials with electroencephalography at day one for familiar and unfamiliar songs and after 2 weeks for newly learned songs

Secondary

Measure	Time frame	Description
Spectral power	day 1 for familiar and unfamiliar songs and day 14 for newly learned songs	Measurements of the spectral power with electroencephalography at day one for familiar and unfamiliar songs and after 2 weeks for newly learned songs

Countries

France

Contacts

Primary ContactDamien Gabriel, PhD

dgabriel@chu-besancon.fr0033381219148

Backup ContactMagali Nicolier, PhD

mnicolier@chu-besancon.fr0033381219007

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026