Spinal Anesthesia Associated With General Anesthesia in Coronary Artery Bypass

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02840006

Enrollment

Registered

2016-07-21

Start date

2014-09-30

Completion date

Unknown

Last updated

2016-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Revascularization, Spinal Anesthesia, Postoperative Care, Fentanyl

Keywords

Vasoconstrictor Agents, Vasodilator Agents

Brief summary

CONTEXT: In patients eligible for coronary artery bypass surgery, anesthesia should provide a number of conditions that exceed the limits of cardiovascular stability, myocardial protection and other organs. Moreover, the combination of general anesthesia and spinal anesthesia lessens the homeostatic, metabolic, hormonal and immunosuppressive changes. The goal of this research was to evaluate the consumption of fentanyl citrate in intra-operative in Coronary Artery Bypass Grafting (CABG) surgery with cardiopulmonary bypass under spinal anesthesia associated with general anesthesia. METHODS: Clinical, prospective, randomized and double covered study, approved by the Research Ethics Committee. Fifty-six patients candidates for CABG with CPB, after signing the Terms of consent, were randomized and divided into two groups: GI - General and GII - General + subarachnoid. General anesthesia was induced according to the weight of each patient and maintenance with isoflurane and fentanyl. Spinal anesthesia was induced with 20 mg of 0.5% hyperbaric bupivacaine and 200 mcg of morphine, the patient is placed in cephalo-position slope of 45 degrees for 10 minutes in Group II. In the statistical study was performed using the Mann-Whitney test; the level of statistical significance was set at 5%.

Interventions

PROCEDUREGeneral anesthesia only

Induction drugs: Citrate of fentanyl, atracurium, etomidate

PROCEDUREGeneral anesthesia and Spinal anesthesia

Induction drugs: Citrate of fentanyl, atracurium, etomidate Spinal anesthesia: Bupivacaine hyperbaric, Morphine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients of both genders * Underwent cardiac artery bypass surgery with cardiopulmonary bypass, with * No restriction on age * No restriction on ethnicity * No restriction on education or social class

Exclusion criteria

* Patients with sternotomy provided; those * Urgent surgery and/or emergency * Patient was with signs of shock * Patients with chronic renal failure * Patients with liver disorders * Tracheostomy patients * Patients with presence of use of mechanical ventilatory support; * Patients with physical disabilities; bedridden and wheelchair users. * Patients to withdraw the Consent and Informed * Patients who eventually had to be re-operated in the presence also of the mechanical ventilatory support.

Design outcomes

Primary

Measure	Time frame	Description
consumption of fentanyl citrate in intra-operative in Coronary Artery Bypass Grafting surgery with cardiopulmonary bypass under spinal anesthesia associated with general anesthesia.	in 24 hours	Will be measure the consumption of fentanyl in 24 hours

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026