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The Effect of Nutritional Interventions on Exercise-induced Muscle Damage

The Effect of Nutritional Interventions on Exercise-induced Muscle Damage

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02839525
Enrollment
2
Registered
2016-07-21
Start date
2016-07-26
Completion date
2017-02-09
Last updated
2017-03-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle Damage

Keywords

Eccentric exercise, Dietary supplement, Muscle damage

Brief summary

The study is a randomized, double-blinded, placebo-controlled trial that will include the participation of 69 women, aged 18-40 years. The aim of the study is to test nutritional strategies that help to minimize the effects of muscle damage induced by exercise. The procedures will be performed at the Federal University of Health of Porto Alegre (UFCSPA).

Detailed description

The exercise-induced muscle damage is associated with eccentric activities affecting muscle structural unit through micro-injury that can promote a local inflammatory response, muscle damage and delayed onset muscle soreness. These events can cause an impact on athletic performance and lower adherence to the training programs. To optimize muscle recovery after the damage caused by exercise is essential to ensure adequate caloric intake , with required amounts of macronutrients and micronutrients. Recent studies have been showed that the protein intake before sleeping is a effective strategy to inhibit muscle protein degradation, stimulate muscle protein synthesis and facilitate adaptive response of skeletal muscle to physical exercise. Furthermore, evidences on the use of anti-inflammatory nutrients have suggested that diets rich in omega 3 can reduce inflammation through inhibition of pro-inflammatory mediators. Therefore, the intake of this nutrient combined with a protein meal before sleeps and the control of food intake can improve adherence to sports training. The study will consist of three groups where everyone will receive an individualized diet. A randomization procedure will determine the type of intervention. The distribution of the groups will be as follows: group 1 (control) - volunteers follow individualized diet and olive oil capsules and maltodextrin; group 2 - intervention with omega 3 more individualized diet ; group 3 - omega 3 and whey protein isolate intervention more individualized diet. The order of procedures to be performed will be: (1) Nutritional and Anthropometric assessment; (2) Individual orientation of diet and distribution of supplements; (3) Baseline assessment (peak torque, muscle pain levels and vastus lateralis and rectus femoris echo intensity; (4) Muscle damage induction by eccentric exercise protocol; (5) Reviews after 24h, 48h, 72h, which will follow the routine and the methods applied at baseline.

Interventions

DIETARY_SUPPLEMENTOmega 3

3000mg of n-3 oil (2000mg EPA e 1000mg DHA)

DIETARY_SUPPLEMENTIsolate whey protein

23g of protein of whey protein

DIETARY_SUPPLEMENTOmega 3 and Isolate whey protein

3000mg of n-3 oil (2000mg EPA e 1000mg DHA) and 23g of protein of whey protein

OTHEREccentric exercise

100 maximal eccentric contractions of knee extensors, divided into 10 sets of 10 repetitions at intervals of 60 seconds between the series

Sponsors

Federal University of Health Science of Porto Alegre
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

* 18 - 40 years aged * BMI 18,5-25kg/m2 * physical exercise: \< 150 minutes per week

Exclusion criteria

* pregnancy/ lactation * vegetarian/vegan * chronic disease * pulmonary and neurologic disease * muscle injury/knee muscle injury * medication use: anti-inflammatory and anticoagulant * fish oil and derivate allergy * dietary supplements use in the last month: whey protein, casein, albumin, glutamin, meat and soy protein, creatine, branched chain amino acid, high calorie supplement, n-3 supplement and antioxidants

Design outcomes

Primary

MeasureTime frameDescription
Quadriceps muscle strength evaluation (Peak Torque)One YearThree maximal isometric contractions of knee extensors will be performed by the isokinetic dynamometer equipment Biodex System 4 Pro (Biodex Medical Systems, USA).

Secondary

MeasureTime frameDescription
Evaluation of quadriceps muscle pain (Muscle pain levels)One yearThe assessment of pain as muscle damage marker is expressed by a visual analog scale.
Vastus lateralis and rectus femoris echo intensityOne yearUltrasound images

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 15, 2026