Influence of Sleep Regularity on Circadian Rhythms, Learning, Performance, and Mood

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02839070

Enrollment

Registered

2016-07-20

Start date

2016-11-01

Completion date

2025-12-01

Last updated

2026-01-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Physiology

Keywords

Sleep, Learning, Circadian Rhythms

Brief summary

The study is a combination of outpatient and inpatient monitoring. During the 27-day inpatient portion of the study, the individual's sleep-wake schedule will be varied daily. Volunteers will be randomized to a regular or irregular inpatient schedule.

Interventions

OTHERSleep/Wake Schedule

Timing of sleep and wake

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy * BMI between 18.5 and 29.5

Exclusion criteria

* medications * recent night-work, shift-work, or travel across \>2 time zones * use of medications * pregnant or within 6 months post-partum

Design outcomes

Primary

Measure	Time frame	Description
Circadian phase	27 days	Circadian phase, as measured by melatonin, at end vs. beginning of inpatient portion of experiment
Learning	27 days	Sleep-dependent learning at 3-4 times during inpatient portion of the experiment
Mood	27 days	Mood (using a linear non-numeric scale) across difference days inpatient portion of the experiment

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORElizabeth B Klerman, MD PhD

Brigham and Women's Hospital

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026