Paroxysmal Atrial Fibrillation
Conditions
Keywords
Right atrium, Echocardiography, Remodeling
Brief summary
The purpose of the study is to assess the reconstruction and inverse reconstruction in right atrium by speckle tracking echocardiography combined with real-time three dimensional echocardiography for atrial fibrillation patients before and after radiofrequency ablation (RFCA)
Detailed description
The prevalence of atrial fibrillation (AF) has increased in recent years. The construction and function of right atrium haven't shown clearly before and after radiofrequency ablation (RFCA).The purpose of the study is to investigate whether RFCA can lead to inverse reconstruction of right atrium for atrial fibrillation patients, which diagnosing by speckle tracking echocardiography combined with real-time three dimensional echocardiography. All patients will be followed up for 12 months.
Interventions
PROCEDUREradiofrequency ablation (RFCA)
Patients undergo radiofrequency ablation (RFCA)
Sponsors
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. With a history of paroxysmal Af (PAF) and PAF record within 6 months prior to ablation, confirming at least one of the following findings: AF lasting for ≥30 s recorded in Holter or 12-lead ECG. 2. No response to more than one antiarrhythmic drug, or unwilling to receive longterm drug treatment. 3. Can provide informed consent form expressing willingness to participate in the study and comply with follow-up tests and evaluation procedures. 4. Aged 18-80 years.
Exclusion criteria
1. With acute diseases, such as acute phase after myocardial infarction (within 3 months), within 3 months after acute heart failure or new cerebral infarction; 2. In the list of heart transplantation; 3. Expected survival less than 1 year; 4. With other hemorrhagic diseases and anticoagulant therapy is not allowed; 5. Thrombosis in left atrium; 6. Heart failure, New York Heart Association(NYHA) III/IV or eject fraction(EF)\<40%; 7. Patients with uncontrolled cancer; 8. Significant hepatic or renal impairment (and/or alanine transaminase(ALT) or Aspartate transaminase(AST) \>2 times upper limit of normal, creatinine clearance rate(CCr)\<50%); 9. Previous catheter radiofrequency ablation for AF or cardiac surgery; 10. Pregnant and lactating women, women who plan to become pregnant, or women of child bearing age not using reliable contraceptive measures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Remodeling in right atrium measured by speckle tracking echocardiography combined with real-time three dimensional echocardiography in AF patients | In one week before RFCA |
Secondary
| Measure | Time frame |
|---|---|
| Remodeling in right atrium measured by speckle tracking echocardiography combined with real-time three dimensional echocardiography in AF patients | In one week after RFCA |
| Inverse reconstruction in right atrium measured by speckle tracking echocardiography combined with real-time three dimensional echocardiography in AF patients | At three months after RFCA |
| Adverse event that is related to RFCA, such as the incidence of cardiac tamponade (%) was obtained by echocardiography | In one week after RFCA |
Other
| Measure | Time frame |
|---|---|
| Adverse events that are related to RFCA, such as the incidence of pulmonary vein stenosis(%) and embolism(%) were obtained by CT | At six months after RFCA |
Countries
China
Contacts
Primary ContactKun Sun, M.D.;Ph.D.
Backup ContactYi Yu, M.D.
Outcome results
None listed