Stomach Neoplasms
Conditions
Keywords
Gastric cancer, gastrojejunostomy, isoperistaltic, antiperistaltic
Brief summary
Billroth-II (gastrojejunostomy) is one of major option after gastrectomy for gastric cancer. The investigators hypothesized that isoperistaltic anastomosis lead to higher incidence of dumping syndrome but antiperistaltic (anisoperistaltic) anastomosis have relevance to gastric stasis or obstruction. The investigators will assess complications, dumping syndrome and quality of life between isoperistaltic and antiperistaltic after distal gastrectomy for gastric cancer.
Detailed description
Recently, laparoscopic approach has been a option for gastric cancer, especially early gastric cancer. There are growing interest in quality of life in addition to recurrence or survival. There are few report about peristalsis and no report for quality of life according to a direction of peristalsis.
Interventions
PROCEDUREIsoperistaltic
Same direction of peristalsis between stomach and jejunum, efferent loop of jejunum is located on the distal part of remnant stomach
PROCEDUREAntiperistaltic
Reverse direction of peristalsis between stomach and jejunum, efferent loop of jejunum is located on the proximal part of remnant stomach
Sponsors
Keimyung University Dongsan Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Histologically confirmed adenocarcinoma in stomach * Scheduled as laparoscopic distal gastrectomy (tumor located lower or middle third) * Planned with gastrojejunostomy after gastrectomy * Clinical stage T1N0M0 or T2N0M0 * ECOG 0 or 1 (The Eastern Cooperative Oncology Group) * ASA score class I-III (The American Society of Anesthesiologists) * patient has given their written informed consent to participate in the study
Exclusion criteria
* Simultaneously combined resection of other organ (including cholecystectomy) * Active other malignancy * Requiring total gastrectomy * Chronic inflammatory bowel disease or other chronic disease related to bowel motility * Uncontrolled diabetes or patients with diabetic complications * Vulnerable patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dumping syndrome | 12 months | Using Sigstad's score |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| long-term complication | from 1 month to 12 months | all kind of complication |
| Total score of quality of life questionnaire | 12 months | by EORTC questionnaire |
| Body weight change | 12 months | for evaluate nutritional status |
| Surgical complication | within 1 month | all kind of complication within 1 month |
| Gastritis | 12 months | by endoscopic evaluation |
Countries
South Korea
Contacts
Primary ContactSeung Wan Ryu, M.D., Ph.D.
Outcome results
None listed