Prion Diseases
Conditions
Brief summary
The human Prion diseases can be classified into sporadic, acquired and inherited forms. Inherited forms usually manifest in higher age so there have to be factors preventing Prion propagation in young mutation carriers. Antibodies against the flexible tail of Prions have been shown to be protective in mice. The investigators intend to screen mutation carriers and controls for the presence of Prion autoantibodies.
Interventions
OTHERblood draw
Sponsors
University of Zurich
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
1 Years to 99 Years
Healthy volunteers
Yes
Inclusion criteria
* Relatives of patients of genetic Prion diseases * Obtained informed consent
Exclusion criteria
* No informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anti-Prion protein autoantibody levels | Baseline, up to 90 years |
Countries
Austria, Germany, Israel, Italy, Slovakia, Switzerland, United States
Outcome results
None listed