Potential Diagnostic and Prognostic Value of microRNAs for the Patients of Sepsis-induced Myocardial Injury

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02835573

Enrollment

100

Registered

2016-07-18

Start date

2016-04-30

Completion date

2018-12-31

Last updated

2018-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis-induced Myocardial Injury

Brief summary

The purpose of this study is to evaluate the potential diagnostic and prognosis value of circulating microRNAs compared with cTnI for the patients of sepsis-induced myocardial injury at the emergency department (ED) and intensive care unit (ICU).

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Yes

Inclusion criteria

1. Diagnosis of sepsis:SOFA score increase \>=2 at baseline level induced by infection. 2. Suspected myocardial injury,including 1 as follows at least:Low blood pressure or using vasoactive drugs; ECG changes(ST segment changes or pathological Q wave); Troponin elevation(\> 0.5 μg/L); BNP elevation(\> 4670pg/ml); Echocardiography: cardiac function decline(EF\<50%).

Exclusion criteria

1. Skeletal muscle damage (induced by orthopedics, vascular surgery or trauma surgical disease, surgery); 2. Pregnant and lactating women; 3. Patients with mental disorders; 4. Patients are using other experimental drugs; 5. Refusal to provide informed consent

Design outcomes

Primary

Measure	Time frame
Diagnostic value of microRNAs evaluate by qPCR in patients of sepsis-induced myocardial injury	Day 7

Secondary

Measure	Time frame
Prognostic value of microRNAs in patients of sepsis-induced myocardial injury	6 months

Countries

China

Outcome results