Inflammatory and Acquired Dysimmune Diseases
Conditions
Keywords
cardiovascular event, risk factors, inflammatory diseases and acquired dysimmune
Brief summary
The hypothesis is that chronic inflammatory dysimmune state promotes the development of cardiovascular complications. The biological assumption is based on the fact that chronic inflammation promotes lesions of the vessel wall (endothelial alterations, calcification, atherosclerosis). The clinical aim is to allow to identify high-risk patients and to act in prevention. The project CARMIN involves the assessment of cardiovascular risk factors, their management, and their influence on cardiovascular prognosis in patients with autoimmune diseases and immunodeficiencies acquired. It is based on the creation and monitoring of a cohort of patients with different types of dysimmune disorders: systemic lupus erythematosus, rheumatoid arthritis, psoriasis, scleroderma, systemic vasculitis ANCA, kidney transplants, and hematopoietic stem cells transplants.
Interventions
OTHERData collection
Risk factors will be collected retrospectively (5 years) and cardiovascular events prospectively (2 years)
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients followed in the various services of medical specialties pole of the Edouard Herriot hospital * The diagnosis of the pathology selected for this study based on a clear clinical and biological evaluation supported by criteria specific to each pathology and compatible with international standards. * Date of diagnosis should not be less than 5 years (+/- 1 year), except for scleroderma patients where it has been extended to 10 years. * For kidney transplant patients the investigators take into account only patients with a maximum of 2 years of dialysis before graft.
Exclusion criteria
* Diabetic patients * HIV seropositive * Patients with multiple pathologies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The occurrence of any cardiovascular event (will be recorded from the patient files and/or phone calls to patient) | 2 years | The cardiovascular events : cardiovascular death, myocardial infarction, stroke, peripheral arterial disease, ischemic manifestations in other territories, heart failure, arrhythmia, deep vein thrombosis or pulmonary embolism. |
Outcome results
None listed