Comparison of Volatile Anesthetics on Cerebral Oxygenation During Controlled Hypotension

Comparison of Effects of Sevoflurane and Desflurane on Cerebral Oxygenation During Controlled Hypotension

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02834845

Enrollment

Registered

2016-07-15

Start date

2016-06-30

Completion date

2016-08-31

Last updated

2020-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oxygen Saturation

Brief summary

Controlled hypotension is a preferred method for reducing surgical bleeding during septoplasty operations however, the level of hypotension and bradycardia should not disrupt cerebral oxygenation. On this account, the investigators aim to investigate the effects of different volatile anesthetics combined with a short-acting opioid on cerebral oxygenation during controlled hypotension using near infrared spectroscopy.

Interventions

DRUGSevoflurane

Sevoflurane %2-3 for general anesthesia maintenance

DRUGDesflurane

Desflurane %6-8 for general anesthesia maintenance

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Patients in American Society of Anesthesiology (ASA) classification I and II * Patients undergoing elective septoplasty operation

Exclusion criteria

* Patients in ASA classification III and higher * Emergency surgery * Patients in New York Heart Association classification III-IV * Patients with known allergy to drugs used in the study

Design outcomes

Primary

Measure	Time frame	Description
Cerebral oxygen saturation as measured by Near Infrared Spectroscopy	Duration of surgery	The effect of sevoflurane and desflurane on NIRS values

Secondary

Measure	Time frame	Description
Total remifentanil consumption as measured in micrograms	Duration of surgery	—
The effect of anesthetics on hemodynamic variables	Duration of surgery	The effects of sevoflurane and desflurane on mean arterial pressure

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026